Abstract
N-(4-[4-¿2, 3-dichlorophenyl¿-1-piperazinyl]butyl)-3-fluorenylcarboxamide and N-(4-[4-¿2, 3-dichlorophenyl¿-1-piperazinyl]butyl)-2-biphenylenylcarboxamide were prepared in several steps from 2,3-dichloroaniline. These compounds were identified as highly selective dopamine D3 receptor antagonists.
MeSH terms
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Animals
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CHO Cells / drug effects
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CHO Cells / metabolism
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Cricetinae
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Dopamine Antagonists / chemical synthesis
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Dopamine Antagonists / metabolism
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Dopamine Antagonists / pharmacology*
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Dopamine D2 Receptor Antagonists*
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Fluorenes / chemical synthesis
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Fluorenes / metabolism
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Fluorenes / pharmacology*
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Humans
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Kinetics
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Piperazines / chemical synthesis
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Piperazines / metabolism
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Piperazines / pharmacology*
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Rats
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Receptors, Dopamine D2 / metabolism
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Receptors, Dopamine D3
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Transfection
Substances
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DRD3 protein, human
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Dopamine Antagonists
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Dopamine D2 Receptor Antagonists
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Drd3 protein, rat
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Fluorenes
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NGB 2849
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NGB 2904
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Piperazines
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Receptors, Dopamine D2
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Receptors, Dopamine D3